It is apparent that proton transport plays an important role in many essential hepatocyte functions. Important unanswered issues include the location of the H+-ATPase and its role in hepatic functions, the regulators of Na+-H+ exchange, the exact role of Na+-H+ exchange in bile formation and in hepatic regeneration, and the role of bile acids such as UDCA and nor-UDCA in mediating transepithelial proton transport.
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| http://dx.doi.org/10.1146/annurev.ph.49.030187.000441 | DOI Listing |
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