Introduction: Chronic low back pain (LBP) is a common and costly health problem yet current treatments demonstrate at best, small effects. The concurrent application of treatments with synergistic clinical and mechanistic effects may improve outcomes in chronic LBP. This pilot trial aims to (1) determine the feasibility, safety and perceived patient response to a combined transcranial direct current stimulation (tDCS) and sensorimotor retraining intervention in chronic LBP and (2) provide data to support a sample size calculation for a fully powered trial should trends of effectiveness be present.
Methods And Analysis: A pilot randomised, assessor and participant-blind, sham-controlled trial will be conducted. Eighty participants with chronic LBP will be randomly allocated to receive either (1) active tDCS + sensorimotor retraining or (2) sham tDCS + sensorimotor retraining. tDCS (active or sham) will be applied to the primary motor cortex for 20 min immediately prior to 60 min of supervised sensorimotor retraining twice per week for 10 weeks. Participants in both groups will complete home exercises three times per week. Feasibility, safety, pain, disability and pain system function will be assessed immediately before and after the 10-week intervention. Analysis of feasibility and safety will be performed using descriptive statistics. Statistical analyses will be conducted based on intention-to-treat and per protocol and will be used to determine trends for effectiveness.
Ethics And Dissemination: Ethical approval has been gained from the institutional human research ethics committee (H10184). Written informed consent will be provided by all participants. Results from this pilot study will be submitted for publication in peer-reviewed journals.
Trial Registration Number: ACTRN12616000624482.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577893 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2016-013080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A click-based electrocorticographic brain-computer interface enables long-term high-performance switch scan spelling.
Commun Med (Lond)
October 2024
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Brain-computer interfaces (BCIs) can restore communication for movement- and/or speech-impaired individuals by enabling neural control of computer typing applications. Single command click detectors provide a basic yet highly functional capability.
Methods: We sought to test the performance and long-term stability of click decoding using a chronically implanted high density electrocorticographic (ECoG) BCI with coverage of the sensorimotor cortex in a human clinical trial participant (ClinicalTrials.
Wearable technology mediated biofeedback to modulate spine motor control: a scoping review.
BMC Musculoskelet Disord
October 2024
Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada.
Background: Lower back pain (LBP) is a disability that affects a large proportion of the population and treatment for this condition has been shifting towards a more individualized, patient-centered approach. There has been a recent uptake in the utilization and implementation of wearable sensors that can administer biofeedback in various industrial, clinical, and performance-based settings. Despite this, there is a strong need to investigate how wearable sensors can be used in a sensorimotor (re)training approach, including how sensory biofeedback from wearable sensors can be used to improve measures of spinal motor control and proprioception.
View Article and Find Full Text PDFNeural subspaces of imagined movements in parietal cortex remain stable over several years in humans.
J Neural Eng
August 2024
Division of Biology and Biological Engineering, and T&C Chen Brain-Machine Interface Center, California Institute of Technology, Pasadena, CA, United States of America.
A crucial goal in brain-machine interfacing is the long-term stability of neural decoding performance, ideally without regular retraining. Long-term stability has only been previously demonstrated in non-human primate experiments and only in primary sensorimotor cortices. Here we extend previous methods to determine long-term stability in humans by identifying and aligning low-dimensional structures in neural data.
View Article and Find Full Text PDFAmplify Gait to Improve Locomotor Engagement in Spinal Cord Injury (AGILE SCI) trial: study protocol for an assessor blinded randomized controlled trial.
BMC Neurol
August 2024
Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA.
Background: Among ambulatory people with incomplete spinal cord injury (iSCI), balance deficits are a primary factor limiting participation in walking activities. There is broad recognition that effective interventions are needed to enhance walking balance following iSCI. Interventions that amplify self-generated movements (e.
View Article and Find Full Text PDFAssessment of Foot Strike Angle and Forward Propulsion with Wearable Sensors in People with Stroke.
Sensors (Basel)
January 2024
Department of Research, Sint Maartenskliniek, 6500 GM Nijmegen, The Netherlands.
Effective retraining of foot elevation and forward propulsion is a critical aspect of gait rehabilitation therapy after stroke, but valuable feedback to enhance these functions is often absent during home-based training. To enable feedback at home, this study assesses the validity of an inertial measurement unit (IMU) to measure the foot strike angle (FSA), and explores eight different kinematic parameters as potential indicators for forward propulsion. Twelve people with stroke performed walking trials while equipped with five IMUs and markers for optical motion analysis (the gold standard).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!