CuCl/EtN-Catalyzed Synthesis of Indanone-Fused 2-Methylene Pyrrolidines from Enynals and Propargylamines.

Org Lett

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Published: September 2017

An efficient CuCl/EtN-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of EtN was found as the key factor for the success of the tandem reaction.

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http://dx.doi.org/10.1021/acs.orglett.7b02121DOI Listing

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