: A Rare Intracerebral Fungal Abscess-Case Series and Review of Literature.

 Intracerebral may carry up to a 70% mortality rate despite advances in surgical resection capabilities and the use of both systemic and intrathecal antifungal treatments.  The authors examined a retrospective case series of two patients with intracerebral infection from the rare, neurotropic fungus and conducted a literature review to evaluate optimal therapies.  At our institution, the patients' cases presented with raised intracranial features of headache, visual field cut, and/or memory loss, with a correspondingly wide variety of radiological differential diagnoses. It was the microbiological, histopathological, and genomic identification of that ensured targeted, individualized patient therapies.  Successful treatment depends on obtaining a complete surgical resection, an accurate microbiological diagnoses for mold identification, and an effective long-term, personalized antifungal treatment. Close radiographic surveillance is necessary to ensure complete eradication of pheoid fungi.