Advanced non-cardia gastric cancer and infection in Vietnam.

Background: The incidence of gastric cancer in the Northern city, Hanoi is higher than in the Southern city, Ho Chi Minh, Vietnam. We previously reported that m1 genotype might be responsible for the difference between the two cities, however, the study only included non-cancer patients. The aim of this study is to investigate the non-cardia gastric cancer characteristics and the role of virulence on different non-cardia gastric cancer incidence between two cities in Vietnam.

Methods And Results: We recruited 282 non-cardia gastric cancer patients that had undergone gastroscopy in two cities, Ho Chi Minh and Hanoi, Vietnam. Characteristics of non-cardia gastric cancer were late age of onset (mean age, 62.5 years), predominance in males (ratio of males/females; 3.9:1), diffuse type (55.3%), and high prevalence of infection (79.4%). infection and the m1 genotype conferred an increased risk for GC (OR, 2.02; 95% CI 1.4-3.0;  = 0.0003 and OR, 2.7; 95% CI 1.5-4.7;  = 0.001, respectively). Interestingly, the presence of m1 genotype in the gastric cancer group was significantly higher than that in the non-cancer group (68.8% vs 44.9%,  = 0.001) and the significant tendency still observed in Ho Chi Minh (67.6% vs 31.9%,  < 0.0001).

Conclusion: We first describe the characteristics of non-cardia gastric cancer in Vietnam. infection was associated with the development of non-cardia GC. m1 genotype might contribute to incidence differences between the two cities.