AI Article Synopsis

  • A study examined the role of serum ornithine carbamoyltransferase (OCT) in chronic hepatitis and liver cirrhosis in 256 patients and 5 healthy controls, measuring OCT levels and comparing them to disease severity and cytokine/chemokine levels.
  • The results showed that OCT concentrations increased with disease progression: from 21.8 ng/ml in healthy individuals to 121.4 ng/ml in severe cases (F4 stage), and OCT levels correlated with various liver function tests.
  • Additionally, higher OCT concentrations were linked to an increased risk of developing hepatocellular carcinoma (HCC), suggesting that OCT could be a useful marker for assessing disease severity and HCC risk.

Article Abstract

: The involvement of serum ornithine carbamoyltransferase (OCT) in the progression of chronic hepatitis and liver cirrhosis is unclear. : A total 256 patients with chronic hepatitis C and 5 healthy controls were examined. Serum OCT concentrations were measured by enzyme-linked immunosorbent assay. Serum OCT concentrations were compared with serum cytokine and chemokine levels, and with disease severity and development of hepatocellular carcinoma (HCC). : The median OCT concentrations were 21.8 ng/ml for healthy controls, 36.7 ng/ml for F0 stage disease, 48.7 ng/ml for F1 stage, 77.9 ng/ml for F2 stage, 104.8 ng/ml for F3 stage, and 121.4 ng/ml for F4 stage. OCT concentrations were correlated with aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase, platelet counts, indocyanine green retention rate at 15 min, prothrombin times, the molar ratio of branched chain amino acids to tyrosine, and tyrosine. Furthermore, there were significant correlations among OCT concentrations and IP10 and IL18 levels. There were weak correlations between serum OCT concentrations and liver histology. The cumulative incidence of HCC in the high-OCT concentration group (≥75.3 ng/ml) was higher than that in the low-OCT concentration group. The measurement of serum OCT concentration may provide a useful marker of disease severity, and thus could be a useful marker for a high risk of HCC occurrence.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562113PMC
http://dx.doi.org/10.7150/ijms.17641DOI Listing

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