A 32-years-old male developed exfoliating skin lesions in bilateral axillae and groins on D-42 post matched sibling allogeneic transplant. These lesions masqueraded betadine burns with a positive history of betadine application in the affected regions. He gradually developed lesions involving other parts of the body with Glucksberg grade-IV acute GVHD (skin-stage: IV/gut-stage: III). He succumbed to his illness. We present this case to highlight the rare initial presentation of skin GVHD involving localized body regions with sparing of rest of the body and mimicking betadine burns.
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