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Brachytherapy Seed Placement by Robotic Bronchoscopy with Cone-Beam CT Guidance for Peripheral Lung Cancer: A Human Cadaveric Feasibility Pilot.
Int J Radiat Oncol Biol Phys
January 2025
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Purpose: This study evaluates the feasibility of utilizing robotic-assisted bronchoscopy with cone beam computed tomography (RB-CBCT) platform to perform low-dose-rate brachytherapy implants (LDR-BT) in a mechanically ventilated human cadaveric model. Post-implant dosimetry was compared to standard stereotactic body radiation therapy plans (SBRT).
Materials And Methods: The RB-CBCT platform was used to place inert LDR-BT seeds into mechanically ventilated human cadavers with percutaneously injected pseudotumors.
This case report is about an 84-year-old female patient with a history of high-grade serous ovarian carcinoma who was diagnosed with a renal pseudotumor. Initial imaging in February 2023 showed signs of a renal cell carcinoma and possible lung metastases. A CT-guided biopsy and histopathological analysis ruled out malignancy and confirmed a benign inflammatory pseudotumor.
View Article and Find Full Text PDFFeasibility of computed tomography-derived surgical margin assessment in an ex vivo sublobar lung resection model.
Interdiscip Cardiovasc Thorac Surg
December 2024
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Objectives: Computed tomography (CT) imaging of a sublobar resection specimen may inform intraoperative surgical margin assessment. However, consistency with final pathological margins has not been previously evaluated. In this study, we investigated the concordance between surgical margin measurements by CT versus pathology measurements using an ex vivo sublobar lung resection model.
View Article and Find Full Text PDFOsseous tumors of the foot, ankle, and lower leg: a cross-sectional observational study analysing 288 cases.
J Foot Ankle Surg
January 2025
Department of Orthopaedics, University of Toronto, Canada; Department of Orthopaedics, St Michael's Hospital, Toronto, Canada.
Article Synopsis
- Osseous tumors of the foot and ankle are rare, representing only 3% of bone neoplasms, and distinguishing between benign and malignant types can be challenging, leading to misdiagnosis and litigation risks.
- A study analyzed 288 cases over 10 years, finding most new referrals were benign tumors (52.4%), with notable examples being osteoid osteoma and osteosarcoma, stressing the importance of early and accurate diagnosis as symptoms often persisted for an average of 5 months before referral.
- The conclusion emphasizes the need for improved understanding and recommended management protocols to help reduce misdiagnoses and improve treatment outcomes for these conditions.
Therapy-Related Acute Promyelocytic Leukemia: Case Series and Current Insights.
Eur J Haematol
January 2025
Hematology Unit, Department of Onco-Hematology, A.O. of Cosenza, Cosenza, Italy.
Article Synopsis
- Therapy-related acute promyelocytic leukemia (t-APL) is a rare condition often arising from treatments like alkylating agents or topoisomerase II inhibitors.
- The report details three cases of t-APL at Cosenza Hospital, each requiring unique treatments following different cancer therapies.
- Notable outcomes include a complete remission in one patient treated with ATRA, while another faced severe complications but also achieved remission; the third patient, however, sadly died due to complications during treatment.
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