AI Article Synopsis
- Researchers isolated a new compound called salvibuchanic acid and five other known compounds from the roots of the Salvia buchananii plant using various spectroscopic methods for structural analysis.
- Both salvibuchanic acid and hyptadienic acid were tested for cytotoxic effects on cancer cell lines (Jurkat, HeLa, and MCF7) and exhibited significant antiproliferative activity.
- Further studies revealed that hyptadienic acid specifically caused a block in the S phase of the cell cycle in HeLa cells, while salvibuchanic acid showed both cytostatic (stopping cell growth) and cytotoxic (killing cells) effects.
Article Abstract
A pentacyclic triterpene, named salvibuchanic acid (1), together with five known compounds, were isolated from the roots of Salvia buchananii Hedge (Lamiaceae). The structural characterisation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HRESIMS experiments. The lupane triterpene (1) and hyptadienic acid (2) were investigated for their potential cytotoxic activity on Jurkat, HeLa and MCF7 cell lines. Both compounds showed an interesting antiproliferative activity with similar potency in all cell lines. By means of flow cytometric studies, hyptadienic acid (2) induced in HeLa cells a S cell cycle block, while 1 elicited both cytostatic and cytotoxic responses.
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| http://dx.doi.org/10.1080/14786419.2017.1365072 | DOI Listing |
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