AI Article Synopsis
- The study aimed to understand how surgical decompression affects the healing and inflammation in periapical cysts by analyzing specific biomarkers before and after the procedure.
- Nine periapical cyst specimens underwent decompression and were thoroughly examined for the expression of various inflammatory and tissue repair biomarkers, with no significant differences found after the procedure.
- Results indicated that decompression effectively shrank the cysts, but it did not alter the levels of proinflammatory or tissue repair biomarkers in the analyzed samples before and after surgery.
Article Abstract
Objective: The biologic effects of surgical decompression on the epithelium and connective tissues of periapical cysts are not fully understood. The aim of this study was to evaluate the expression of tissue repair and inflammatory biomarkers in periapical cysts before and after surgical decompression.
Study Design: Nine specimens of periapical cysts treated with decompression before undergoing complete enucleation were immunohistochemically analyzed to investigate the expression of interleukin-1β, tumor necrosis factor-α, transforming growth factor-β1, matrix metalloproteinase-9, Ki-67, and epidermal growth factor receptor. Expression of the biomarkers was classified as positive, focal, or negative. Ki-67 immunoexpression was calculated as a cell proliferation index. The expression of the biomarkers was compared in the specimens from decompression and from the final surgical procedure.
Results: Computed tomography demonstrated that volume was reduced in all cysts after decompression. There were no differences in the immunoexpression of the proinflammatory and tissue repair biomarkers when comparing the specimens obtained before and after the decompression.
Conclusions: Surgical decompression was efficient in reducing the volume of periapical cysts before complete enucleation. When comparing the specimens obtained from surgical decompression and from complete surgical removal, the immunohistochemical analysis did not show a decrease in proinflammatory biomarkers; neither did it show an increase in tissue repair biomarkers.
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| http://dx.doi.org/10.1016/j.oooo.2017.06.121 | DOI Listing |
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