A pectic polysaccharide from Ligusticum chuanxiong promotes intestine antioxidant defense in aged mice.

Carbohydr Polym

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

Published: October 2017

The extensive prospects of polysaccharides in medicine and pharmaceuticals have elicited much interest. Ligusticum chuanxiong polysaccharides, previously extracted as neutral polysaccharides, exhibit antioxidant, anticancer, andantibacterial capacities in vitro. Here we show one pectic polysaccharide extracted from rhizome of L. chuanxiong(LCP-II-I). Structural analysis indicated its long homogalacturonan region is interrupted by rhamnogalacturonan type I, with arabinan and arabinogalactan type I as side chains. Intake of the LCP-II-I significantly promoted the expression of antioxidant enzymes and their master regulator PGC-1α, resulting in higher antioxidant capacity in jejunum and cecum of aged mice. Consistently, treatment with LCP-II-I promotes antioxidant enzymes expression, and protects SW480 cells against HO induced oxidative stress. Our work isolates and identifies a pectic polysaccharide, LCP-II-I, and reveals its potential application in antioxidant defense, which will be important for oxidative stress related disorders treatment in aging intestine.

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http://dx.doi.org/10.1016/j.carbpol.2017.06.122DOI Listing

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