[Lymphocytic myocarditis in a patient with metastatic clear cell renal cell carcinoma treated with Nivolumab].

Pathologe

Institut für Pathologie, MVZ am HELIOS Klinikum Emil von Behring, Walterhöferstr. 11, 14165, Berlin, Deutschland.

Published: November 2017

Immune checkpoint inhibitors against the PD-1 protein offer a new therapy option for many solid cancers. We report a patient with metastatic renal cell cancer treated with Nivolumab. As a rare immune-mediated adverse event, we describe a fatal lymphocytic myocarditis two weeks after starting immune therapy. The cause of death was first diagnosed at autopsy. This case report underlines the importance and need of clinical autopsies as an instrument of quality assurance and detection of rare therapy-induced adverse effects.

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http://dx.doi.org/10.1007/s00292-017-0349-yDOI Listing

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