strain SDL-CO-2015-1, a basidiomycete fungus, was identified as an endophyte from a jute species, var. 2015, and found to produce paclitaxel, a diterpenic polyoxygenated pseudoalkaloid with antitumor activity. Here, we report the draft genome sequence (42.8 Mb with 9,395 genes) of this strain.
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http://dx.doi.org/10.1128/genomeA.00825-17 | DOI Listing |
Target Oncol
January 2025
Hematology-Oncology Service, Department of Medicine, Centre hospitalier de l'Université de Montréal (CHUM), 1000, rue Saint-Denis, Montreal, QC, Canada.
Background: BERIL-1 was a randomized phase 2 study that studied paclitaxel with either buparlisib, a pan-class I PIK3 inhibitor, or placebo in patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC). Considering the therapeutic paradigm shift with immune checkpoint inhibitors (ICIs) now approved in the first-line setting, we present an updated immunogenomic analysis of patients enrolled in BERIL-1, including patients with immune-infiltrated tumors.
Objective: The objective of this study was to identify biomarkers predictive of treatment efficacy in the context of the post-ICI therapeutic landscape.
Microbiol Resour Announc
January 2025
Plant Sciences, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
This study reports draft genomes of 30 bacteria representative of the plant food system microbiota and isolated from different sources in Italy and France. Individual genomes were reconstructed using PacBIO DNA sequencing: taxonomic classification and distribution of genes involved in microbe-environment interactions are reported to facilitate strains' characterization and utilization.
View Article and Find Full Text PDFMicrobiol Resour Announc
January 2025
Department of Microbiology, University of Dhaka, Dhaka, Bangladesh.
We present the genome of BDSA isolated from ready-to-eat (RTE) meat collected in Dhaka, Bangladesh. The genome displays the Listeria pathogenicity island 1 and virulence, stress response, and antimicrobial resistance genes. It was phylogenetically classified as ST7, and clustered with serotype 1/2a belonging to lineage II.
View Article and Find Full Text PDFVet Med Int
January 2025
Veterinary Population Medicine Department and Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108, USA.
Bovine papillomaviruses (BPVs) commonly cause sarcoids in equines worldwide. Equine sarcoids (ESs) reduce the working ability of draft animals and produce untoward cosmetic changes in racing and dancing equine. In this study, nine horses and 16 donkeys with sarcoids were presented to Zagazig University Veterinary Clinic, Zagazig, Egypt.
View Article and Find Full Text PDFBMC Biol
January 2025
School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast, Northern Ireland, UK.
Background: The rumen fluke, Calicophoron daubneyi, is the major paramphistome species infecting ruminants within Europe. Adult flukes reside within the rumen where they are in direct contact with a unique collection of microorganisms. Here, we report a 1.
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