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Unlocking soybean meal pectin recalcitrance using a multi-enzyme cocktail approach.
Sci Rep
January 2025
BBF, Biodiversité et Biotechnologie Fongiques, INRAE, Aix-Marseille Univ, Marseille, France.
Article Synopsis
- Pectin is a complex substance in plant cell walls, crucial for breaking down in animal feed to enhance nutrient absorption.
- Significant amounts of pectin are found in soybean meal, a common poultry feed, but its structure and the necessary enzymes for degradation are not well understood.
- The study developed and tested various combinations of fungal enzymes, identifying 10 effective ones for breaking down soybean meal pectin, mainly from the fungus Talaromyces versatilis, and proposes a new structural model for understanding pectin in feed.
The Effectiveness of Platelet Rich Fibrin in Alveolar Ridge Reconstructive or Guided Bone Regenerative Procedures: A Systematic Review and Meta-Analysis.
J Dent
February 2025
Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom. Electronic address:
Introduction And Objectives: Clinical studies have shown favorable outcomes following use of platelet rich fibrin (PRF), either alone or in conjunction with biomaterials for alveolar ridge reconstruction (ARR) or guided bone regeneration (GBR) . While PRF application accelerates wound healing and reduces postoperative discomfort, its effects on the alveolar bone gain, as part of ARR or GBR is less clear. Therefore, this study aims to investigate the clinical effectiveness of PRF when used in ARR or GBR, as well as postoperative discomfort following these procedures.
View Article and Find Full Text PDFGenerative AI: driving productivity and scientific breakthroughs in pharmaceutical R&D.
Drug Discov Today
December 2024
Data Sciences & AI, R&D, Pharmaceuticals, Bayer AG, Berlin, Germany.
The rapid advancement of generative artificial intelligence (AI) is reshaping pharmaceutical research and development (R&D), offering opportunities across drug discovery and development. Generative AI (GenAI) enhances productivity by enabling virtual assistants, which help automate routine tasks. It advances novel small-molecule drug design and drives new machine learning (ML) applications through synthetic data generation.
View Article and Find Full Text PDFTrimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins.
Life Sci
January 2025
Department of Internal Medicine, Metropolitan Hospital Center, New York, NY, USA. Electronic address:
Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.
View Article and Find Full Text PDFProcoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets.
J Vis Exp
November 2024
Department of Haematology, University Hospital of Bordeaux; Inserm U1034, Biology of Cardiovascular Disease.
Activated platelets promote coagulation primarily by exposing the procoagulant phospholipid phosphatidylserine (PS) on their outer membrane surfaces and releasing PS-expressing microvesicles that retain the original membrane architecture and cytoplasmic components of their originating cells. The accessibility of phosphatidylserine facilitates the binding of major coagulation factors, significantly amplifying the catalytic efficiency of coagulation enzymes, while microvesicle release acts as a pivotal mediator of intercellular signaling. Procoagulant platelets play a crucial role in clot stabilization during hemostasis, and their increased proportion in the bloodstream correlates with an increased risk of thrombosis.
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