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Diabetes, cardiorenal, and metabolic multispecialty practice recommendations and early intensive management of cardio-renal-metabolic disease.
Am J Manag Care
December 2024
Metabolic Institute of America, 18372 Clark St #212, Tarzana, CA 91356. Email:
In recent years, evidence has continued to mount showing a strong relationship between diabetes, cardiovascular disease, and chronic kidney disease. This, in turn, has driven a shift to a more integrated and holistic approach in the treatment of patients with cardio-renal-metabolic (CRM) disease. The 2022 Diabetes, Cardiorenal, and Metabolic (DCRM) multispecialty practice recommendations were the first multispecialty consensus on the comprehensive management of patients with diabetes, cardiorenal, and/or metabolic diseases, providing evidence-based recommendations that are simple to implement.
View Article and Find Full Text PDFProcesses and approaches to perioperative pain management in patients undergoing major lower extremity amputations secondary to vascular disease: a multi-specialty modified Delphi consensus study protocol.
BMJ Open
December 2024
Epidemiology Group, University of Aberdeen Institute of Applied Health Sciences, Aberdeen, UK.
Article Synopsis
- * A modified Delphi methodology will be employed to gather opinions from a diverse group of UK experts through a series of anonymous surveys, aiming for consensus on effective pain management techniques.
- * The study seeks to analyze expert agreement using structured feedback and will only continue if a consensus of at least 75% is reached among participants, although ethical approval was deemed unnecessary.
Neurological complications of immune checkpoint inhibitors: a practical guide.
Pract Neurol
November 2024
Department of Neurology, University Hospital of Wales, Cardiff, UK.
Immune checkpoint inhibition unleashes the power of the immune system against tumour cells. Immune checkpoint inhibitors (ICIs) block the inhibitory effects of cytotoxic T-lymphocyte associated protein 4, programmed death protein 1, programmed death ligand 1 and lymphocyte activation gene 3 molecules on T-cells, and so enhance physiological cytotoxic effects. ICIs can significantly improve survival from cancers, including those previously associated with poor treatment response, such as metastatic melanoma.
View Article and Find Full Text PDFSympathetic Overdrive and Role of Beta-blockers in Various Forms of Heart Failure: A Consensus Statement from India.
J Assoc Physicians India
November 2024
Consultant Cardiologist, Medanta Moolchand Heart Center, New Delhi, India.
In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival.
View Article and Find Full Text PDFEvaluation of preoperative cardiopulmonary reserve and surgical risk of patients undergoing lung cancer resection.
Ther Adv Respir Dis
October 2024
Division of Respiratory Disease, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Lung cancer represents the second most frequent neoplasm and the leading cause of neoplastic death among both women and men, causing almost 25% of all cancer deaths. Patients undergoing lung resection-both for primary and secondary tumors-require careful preoperative cardiopulmonary functional evaluation to confirm the safety of the planned resection, to assess the maximum tolerable volume of resection or to exclude surgery, thus shifting the therapeutic approach toward less invasive options. Cardiopulmonary reserve, pulmonary lung function and mechanical respiratory function represent the cornerstones of preoperative assessment of patients undergoing major lung resection.
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