A new Rh-catalyzed, three-component reaction for the oxytrifluoromethylthiolation of α-diazoketones was developed. The SCF functionality was introduced using a stable dibenzenesulfonimide reagent under mild conditions. Alcohols, acetals, and ethers were used as the alkoxy sources. Cyclic ethers underwent a trifunctionalization reaction through the introduction of SCF, OR, and N(SOPh) substituents in a single step.
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| http://dx.doi.org/10.1021/acs.orglett.7b02139 | DOI Listing |
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