[The relationship between periodontitis and arterial sclerosis without genetic confounding].

Purpose: The aim of this study was to evaluate periodontitis as a significant risk factor related to arterial sclerosis after eliminating genetic confounding.

Methods: Fifty two monozygotic twin pairs, 104 patients, were divided into 3 groups. group A: 24 pairs, 48 healthy people, as the blank group; group B: 28 patients with periodontitis, as the control group; group C: 28 patients with periodontitis, as the treatment group. The sample in group B and C had the same gene type. The index of CRP, IL-6, TNF-αand IMT were detected before treatment, 6 and 12 week after treatment. The data were analyzed using SPSS 17.0 software package.

Results: The index of CRP, IL-6, TNF-α and IMT decreased after treatment in group C, there was no significant change in group A and B at each check point.

Conclusions: Periodontitis can promote the development of sclerosis without the intervening of gene.