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Clinical Problem Solving: Two Patients With Gait Instability and Difficulty With Hand Coordination.
Neurohospitalist
January 2025
Instructor in Neurology, Harvard Medical School and Attending Physician, Stroke Division, Brigham & Women's Hospital, Boston, MA, USA.
Subacute-to-chronic gait instability has a broad differential diagnosis. The neurological exam can help elucidate the localization and suggest an underlying etiology of the symptomatology, which can lead to a more focused diagnostic approach. Two patients are described - 1 with a month of worsening difficulty with ambulation that evolved to bilateral hand discoordination and another with 18 months of progressive difficulty with ambulation that also then progressed to involve her bilateral hands.
View Article and Find Full Text PDFSARS-CoV-2 Infection of the Central Nervous System: A Case Report.
Viruses
December 2024
Department of Medical Oncology, Medical University of Sofia, University Hospital "Tsaritsa Yoanna", 1527 Sofia, Bulgaria.
Central nervous system (CNS) infections caused by SARS-CoV-2 are uncommon. This case report describes the clinical progression of a 92-year-old female who developed a persistent neuroinfection associated with SARS-CoV-2. The patient initially presented with progressive fatigue, catarrhal symptoms, and a fever (38.
View Article and Find Full Text PDFQuantitative assessment of dysphagia in myasthenia gravis.
Intern Med
October 2024
Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
Article Synopsis
- Dysphagia, a common symptom in patients with myasthenia gravis (MG), is linked to muscle weakness and a lack of coordination in swallowing and breathing.
- The study recorded breathing patterns and muscle activity during swallowing in 10 MG patients and 22 healthy controls, finding significant differences in their respiratory patterns.
- These findings suggest that monitoring breathing and muscle activity can effectively indicate the severity of swallowing difficulties in MG patients, particularly after treatment.
Uncommon Streptococcus Constellatus Meningitis Leading to Pulmonary Abscess and Brainstem Infarct in an Immunocompetent Patient.
Am J Case Rep
August 2024
Department of Internal Medicine, Baptist Memorial Hospital - North Mississippi, Oxford, MS, USA.
BACKGROUND Except for neonates, streptococci other than Streptococcus pneumoniae are a rare cause of acute bacterial meningitis. Streptococcus constellatus is a member of the Streptococcus anginosus group of gram-positive streptococci. It is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract.
View Article and Find Full Text PDFEscitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Int Immunopharmacol
September 2024
Department of Preventive Medicine and Institute of Nutrition and Diseases, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Neurology and Institute of Geriatric Neurology, the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:
Citalopram and escitalopram are structurally close-related antidepressants and both forms are widely used in the world. We aimed to comparatively evaluate the anti-neuroinflammatory and neuroprotective effects of escitalopram and citalopram in Parkinson's disease (PD) mouse model. Mice were randomly divided into six groups and received 6-hydroxydopamine (6-OHDA) or vehicle administration.
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