Gender and PTSD: different pathways to a similar phenotype.

Curr Opin Psychol

National Center for PTSD, Women's Health Sciences Division, VA Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.

Published: April 2017

Whereas research supports the existence of a single posttraumatic stress disorder (PTSD) phenotype across women and men, there may be important gender differences in the pathophysiology of, or mechanisms underlying, the disorder. This paper reviews recent literature on gender differences in emotional, cognitive, and neurobiological factors, and their relations with PTSD and relevant comorbidities. Key findings and limitations from both human and animal studies are discussed. Overall, more work is needed that utilizes objective measures in addition to self-report. Studies explicitly examining gender differences and those examining mechanisms within single-gender samples each have the potential to improve our understanding of gender discrepancies in PTSD and inform tailored interventions for women and men.

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http://dx.doi.org/10.1016/j.copsyc.2016.11.002DOI Listing

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