Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752 | PMC |
| http://dx.doi.org/10.1038/s41598-017-08267-5 | DOI Listing |
Publication Analysis
Top Keywords
transcription factor
8
factor znf148
8
human muscle
8
muscle differentiation
8
muscle
5
znf148 negative
4
negative regulator
4
regulator human
4
differentiation muscle
4
differentiation complex
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!