We report a theoretical and experimental study of coupling between a whispering-gallery-mode (WGM) microdisk resonator and a fiber taper which exchange energies at two distinct regions. We observe an oscillatory behavior in the coupling strength as a function of the distance between the two coupling regions when a fiber taper is moved laterally above the resonator at fixed vertical distance. This oscillation is clearly seen in the linewidth of the resonance as well as in the on-resonance transmission. A theoretical model considering for two-point coupling successfully explains the experimental observations as being a result of the interference between the light fields coupled into and out of the resonator at two distinct regions and the light transmitted through the waveguide. Critical coupling in two-region coupling is a collective result of the coupling at two different coupling regions, and does not require critical coupling at both or at any one of the two coupling regions. This relaxes the conditions for achieving critical coupling in waveguide-resonator systems. The discovery of this previously unnoticed oscillatory behavior in two-region coupling between a WGM resonator and a waveguide will benefit both fundamental studies and practical applications based on WGM resonators.
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http://dx.doi.org/10.1038/s41598-017-08656-w | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720.
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January 2025
Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214.
Ion channels are generally allosteric proteins, involving specialized stimulus sensor domains conformationally linked to the gate to drive channel opening. Temperature receptors are a group of ion channels from the transient receptor potential family. They exhibit an unprecedentedly strong temperature dependence and are responsible for temperature sensing in mammals.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Research Applications Laboratory, NSF National Center for Atmospheric Research, Boulder, CO 80301.
Precipitation recycling, where evapotranspiration (ET) from the land surface contributes to precipitation within the same region, is a critical component of the water cycle. This process is especially important for the US Corn Belt, where extensive cropland expansions and irrigation activities have significantly transformed the landscape and affected the regional climate. Previous studies investigating precipitation recycling typically relied on analytical models with simplifying assumptions, overlooking the complex interactions between groundwater hydrology and agricultural management.
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January 2025
Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Neurotransmitter release is triggered in microseconds by Ca-binding to the Synaptotagmin-1 C-domains and by SNARE complexes that form four-helix bundles between synaptic vesicles and plasma membranes, but the coupling mechanism between Ca-sensing and membrane fusion is unknown. Release requires extension of SNARE helices into juxtamembrane linkers that precede transmembrane regions (linker zippering) and binding of the Synaptotagmin-1 CB domain to SNARE complexes through a "primary interface" comprising two regions (I and II). The Synaptotagmin-1 Ca-binding loops were believed to accelerate membrane fusion by inducing membrane curvature, perturbing lipid bilayers, or helping bridge the membranes, but SNARE complex binding through the primary interface orients the Ca-binding loops away from the fusion site, hindering these putative activities.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
The homo-dodecameric ring-shaped RNA binding attenuation protein (TRAP) from binds up to twelve tryptophan ligands (Trp) and becomes activated to bind a specific sequence in the 5' leader region of the operon mRNA, thereby downregulating biosynthesis of Trp. Thermodynamic measurements of Trp binding have revealed a range of cooperative behavior for different TRAP variants, even if the averaged apparent affinities for Trp have been found to be similar. Proximity between the ligand binding sites, and the ligand-coupled disorder-to-order transition has implicated nearest-neighbor interactions in cooperativity.
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