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Associations of the Gap Between 2-Hour Post-Load Plasma Glucose and Fasting Blood Glucose With All-Cause or Cardiovascular Mortality in US Normoglycemic Adults.
Biol Res Nurs
January 2025
Department of Laboratory Medicine, Nanjing Pukou People's Hospital, Nanjing, China.
Background: The gap between 2-hour post-load plasma glucose (2 h PG) and fasting blood glucose (FBG) has been shown to be informative of the risk of developing prediabetes and diabetes. We aimed to examine the significance of the gap between 2 h PG and FBG in relation to all-cause or cardiovascular disease (CVD) mortality in normoglycemic adults.
Methods: 3611 normoglycemic participants from the 2005-2016 US National Health and Nutrition Examination Survey were included and dichotomized into the low (2 h PG ≤ FBG) and high post-load (2 h PG > FBG) groups.
The effect of exercise on GDF-15 levels in individuals with prediabetes: A randomized controlled trial.
J Diabetes Investig
January 2025
Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul Medeniyet University, İstanbul, Turkey.
Aims: Growth differentiation factor-15 (GDF-15) is an inflammatory cytokine that increases in prediabetes and is known for its anorexigenic effects. This study aims to evaluate the effects of a 12-week exercise program on GDF-15 in individuals with prediabetes.
Materials And Methods: In this multicenter, parallel-group, randomized-controlled trial, 64 patients aged 18-60 diagnosed with prediabetes were randomized in a 1:1 ratio into the exercise group (E) and the control group (C).
Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes (T2D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of pro-inflammatory eicosanoids and is known to promote the migration of macrophages, yet its role in obesity-associated inflammation remains incompletely understood. Furthermore, differences between mouse and human orthologs of 12-LOX have limited efforts to study existing pharmacologic inhibitors of 12-LOX.
View Article and Find Full Text PDFCross-sectional study on prevalence and risk factors of undiagnosed type 2 diabetes among patients with hypertension attending St. Orsola Catholic Mission Hospital, Tharaka Nithi County, Kenya.
Pan Afr Med J
January 2025
Department of Community Health, School of Public Health, Amref International University, Nairobi, Kenya.
Introduction: according to the World Health Organization (WHO), Non-Communicable Diseases (NCD) were a major cause of death in 2022 accounting for 4 million (74%) of deaths worldwide. Diabetes mellitus and hypertension are the two illnesses that are not contagious but linked closely. The objective of the research was to establish the prevalence and risk factors of undiagnosed diabetes among patients with hypertension attending St.
View Article and Find Full Text PDFHigher Levels of Glucose within the Normal Range and Cardiovascular Risk: A Landscape Beyond Diabetes and Prediabetes.
Am Heart J
January 2025
Division of Cardiology, Geffen School of Medicine at University of California, Los Angeles, California, United States. Electronic address:
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