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The rs1800012 polymorphism is associated with osteoporosis or fracture risk: a meta-analysis of 30 studies.
Int J Burns Trauma
December 2024
Department of Orthopedics, The Second Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Objectives: Osteoporosis is a complex disease that is influenced by several genetic markers. Many studies have examined the link between the gene rs1800012 polymorphism and osteoporosis risk. However, the findings of these studies are contradictory.
View Article and Find Full Text PDFNEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets.
J Orthop Surg Res
January 2025
Department of Orthopedics, the Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Osteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population. Osteoporotic complications, including vertebral compression fractures, hip fractures, and distal forearm fractures, affect over 8.9 million individuals globally, placing a significant economic strain on healthcare systems.
View Article and Find Full Text PDFThe bone-vascular axis: the link between osteoporosis and vascular calcification.
Mol Cell Biochem
January 2025
Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Osteoporosis and vascular calcification are chronic metabolic diseases threatening the health of aging people. The incidence of osteoporosis and vascular calcification increases year by year, and has drawn much attention from the scientific and clinical area. Many studies have found that osteoporosis and vascular calcification are not completely independent, but there are close correlations between them in the pathogenesis and underlying mechanisms.
View Article and Find Full Text PDF[Current surgical treatment concepts for traumatic fractures of the thoracic and lumbar spine with osteoporotic bone substance].
Unfallchirurgie (Heidelb)
January 2025
Klinik für Unfallchirurgie, Orthopädie, Hand- & Wiederherstellungschirurgie, München Klinik Harlaching, München, Deutschland.
Osteoporosis-related vertebral fractures are among the most frequent fracture entities in geriatric patients. They are associated with far-reaching individual and socioeconomic consequences. Adequate diagnostics and treatment are therefore essential.
View Article and Find Full Text PDF[Research progress of bioactive scaffolds in repair and regeneration of osteoporotic bone defects].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2025
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Objective: To summarize the research progress of bioactive scaffolds in the repair and regeneration of osteoporotic bone defects.
Methods: Recent literature on bioactive scaffolds for the repair of osteoporotic bone defects was reviewed to summarize various types of bioactive scaffolds and their associated repair methods.
Results: The application of bioactive scaffolds provides a new idea for the repair and regeneration of osteoporotic bone defects.
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