AI Article Synopsis
- ADP-ribose and its derivatives are essential for various physiological processes, making their artificial synthesis important for chemical biology and drug discovery.
- Creating ADP-ribosylated compounds is challenging due to their complex structure, fragile bonds, and high water affinity.
- This paper introduces the first synthesis of ADP-ribosyl-N₃, which serves as a precursor for a new strategy to produce different ADP-ribosylated compounds, including innovative nucleotides and peptides.
Article Abstract
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N₃ was designed and synthesized for the first time. With ADP-ribosyl-N₃ as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152188 | PMC |
| http://dx.doi.org/10.3390/molecules22081346 | DOI Listing |
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