Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cgh.2017.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gum Resin Mitigates Renal Toxicity: Role of TNF-α, Interleukins, TGF-β, and Lipid Peroxidation.
Life (Basel)
December 2024
Department of Pharmacology and Toxicology (Biochemistry Subdivision), College of Pharmacy, Taibah University, Madinah 41411, Saudi Arabia.
Being a central organ in homeostasis and maintaining the health of the biological system, kidneys are exposed to variable toxicants. Long-term exposure to nephrotoxic molecules causes chronic renal damage that causes fibrosis and loss of function. Such damage can be initiated by oxidative stress which provokes inflammation.
View Article and Find Full Text PDFThe hepatoprotective effects of the polyphenol-enriched n-butanol fraction of against carbon tetrachloride-induced liver fibrosis in rats: study.
Toxicol Rep
June 2025
Department of Pharmacology and Toxicology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.
Liver fibrosis is a continuous wound-healing response to chronic injury caused by various chemical, virus, and pathological disorders; the lack of approved drugs or methods to reverse or prevent liver fibrosis makes it an interesting area of research. This study investigates the potential hepatoprotective effects of the phenolic extract of in rat's module of liver fibrosis. Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl) for six consecutive weeks; the butanol fraction of and silymarin was administered orally concurrently with CCl.
View Article and Find Full Text PDFMechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells.
Cell Biochem Biophys
January 2025
Faculty of Medicine, Department of Histology and Embryology, Eskişehir Osmangazi University, Eskişehir, Türkiye.
Article Synopsis
- Silymarin, a flavonoid from milk thistle, shows promising effects like antioxidant and anti-inflammatory properties, particularly in cancer research.
- In a study on SPC212 human mesothelioma cells, silymarin was found to have a dose-dependent cytotoxic effect, with a half-maximal inhibitory concentration (IC) of about 187.5 µM.
- The compound induced signs of apoptosis, such as cell shrinkage and nuclear changes, suggesting its potential as an anti-cancer agent that needs further investigation.
Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in Rats.
J Pharmacopuncture
December 2024
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Objectives: 5-fluorouracil chemotherapy is a highly recommended treatment for different types of solid tumors. However, this treatment can have severe side effects on the heart and lungs. In this study, we compared the protective effects of citral, silymarin, thymoquinone, and curcumin against 5-fluorouracil-induced toxicity in the heart and lungs of rats.
View Article and Find Full Text PDFThe effect of silymarin on diabetes mellitus-induced male rats reproductive impairment: Evidences for role of heat shock proteins 70 and 90.
Pol J Vet Sci
December 2024
Department of Basic sciences, Faculty of Veterinary Medicine, Tabriz medical sciences branch, Islamic Azad University, 5159115705, Tabriz, Iran.
Male fertility is adversely influenced by diabetes. The beneficial effects of antioxidant bioflavonoids in improving fertility have been reported. This study was conducted to evaluate the effects of silymarin on diabetes mellitus-induced male reproductive impairment in rats by investigating its role in Hsp70 and Hsp90 expression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!