AI Article Synopsis
- The study aimed to assess the effectiveness of two auditory brainstem response (ABR) tests in diagnosing schizophrenia and adult ADHD through a blinded investigation involving 108 participants.
- Results showed that the ABR test for schizophrenia had a sensitivity of 84.6% and a specificity of 93.1%, while the ADHD test showed a sensitivity of 87.5% and a specificity of 91.4%.
- The findings suggest that ABR profiling tests can effectively differentiate between patients with schizophrenia and ADHD from healthy controls, indicating potential for future research as diagnostic tools for various psychiatric disorders.
Article Abstract
Objective: To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design.
Method: Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119). Coded sets of randomized ABR recordings were analysed by an independent party blinded to clinical diagnoses before a joint code-breaking session.
Results: The ABR profiling test for schizophrenia identified schizophrenia patients versus controls with a sensitivity of 84.6% and a specificity of 93.1%. The ADHD test identified patients with adult ADHD versus controls with a sensitivity of 87.5% and a specificity of 91.4%.
Conclusion: The ABR profiling tests discriminated schizophrenia and ADHD versus healthy controls with high sensitivity and specificity. The methods deserve to be further explored in larger clinical studies including a broad range of psychiatric disorders to determine their utility as potential diagnostic biomarkers.
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| http://dx.doi.org/10.1017/neu.2017.24 | DOI Listing |
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