AI Article Synopsis
- DevR/DosR is crucial for Mycobacterium tuberculosis to adapt to dormancy under low-oxygen stresses, impacting its ability to respire aerobically.
- Long-term analysis showed that genes associated with the DevR regulon, such as devR, hspX, and tgs1, were actively expressed during prolonged hypoxic conditions.
- The study highlights the continuous expression of HspX and triacylglycerol buildup as key factors in M. tuberculosis's survival strategy, suggesting DevR as a potential target for treatments against dormant bacterial populations.
Article Abstract
DevR/DosR is a key mediator of 'dormancy' adaptation in Mycobacterium tuberculosis in response to gaseous stresses such as hypoxia that inhibit aerobic mode of respiration. In the present study, a temporal analysis over a 1 year period has revealed robust expression of representative DevR regulon genes devR, hspX and tgs1, during long-term 'dormancy' adaptation to hypoxia. Notably, a predominant proportion of long-term hypoxia-adapted bacteria were characterized by their inability to grow on solid media, accumulation of triacylglycerols and recovery of growth in liquid media. Persistent expression of HspX and the accumulation of triacylglycerols reveal a previously underappreciated role of DevR during adaptation to extended hypoxia, and endorse DevR as an effective target for thwarting the sustained survival of 'dormant' subpopulation of M. tuberculosis.
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| http://dx.doi.org/10.1016/j.tube.2017.06.003 | DOI Listing |
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