AI Article Synopsis
- Diabetic complications arise from prolonged high blood sugar levels and are a complex metabolic disorder.
- The study suggests that using multi-targeted agents is more effective than single-target drugs for treating these complications.
- Researchers designed and tested new compounds, specifically thiazolidine-2,4-dione analogues, which showed promising results in affecting key enzymes related to diabetic complications, indicating potential for affordable treatment options.
Article Abstract
Diabetic complications is a complex metabolic disorder developed primarily due to prolonged hyperglycemia in the body. The complexity of the disease state as well as the unifying pathophysiology discussed in the literature reports exhibited that the use of multi-targeted agents with multiple complementary biological activities may offer promising therapy for the intervention of the disease over the single-target drugs. In the present study, novel thiazolidine-2,4-dione analogues were designed as multi-targeted agents implicated against the molecular pathways involved in diabetic complications using knowledge based as well as in-silico approaches such as pharmacophore mapping, molecular docking etc. The hit molecules were duly synthesized and biochemical estimation of these molecules against aldose reductase (ALR2), protein kinase Cβ (PKCβ) and poly (ADP-ribose) polymerase 1 (PARP-1) led to identification of compound 2 that showed good potency against PARP-1 and ALR2 enzymes. These positive results support the progress of a low cost multi-targeted agent with putative roles in diabetic complications.
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| http://dx.doi.org/10.1016/j.jmgm.2017.07.020 | DOI Listing |
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