AI Article Synopsis
- * The review highlights the role of mobile genetic elements, particularly non-LTR retrotransposons, which have influenced our genome over time.
- * Key events in primate evolution include various phases of LINE retrotransposition and the emergence of new mobile elements like Alu and SVA, which may have affected brain development.
Article Abstract
Researchers have long sought to understand the genetic basis of the cognitive differences between primates, with particular focus on the human brain. Although all mutational types have worked in concert with evolutionary forces to generate the current human brain, in this review we will explore the impact of mobile elements, specifically non-LTR retrotransposons. Non-LTR retrotransposons have contributed coding and regulatory sequences to the genome throughout evolution. During primate evolution there have been multiple waves of LINE retrotransposition as well as the birth of new mobile elements such as the SINEs Alu and SVA and we will explore what kinds of impacts these may have had on the evolving human brain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554003 | PMC |
| http://dx.doi.org/10.1186/s12915-017-0409-z | DOI Listing |
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