Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics?

Med Mal Infect

Inserm, U995, Lille inflammation research international center (LIRIC), university of Lille, 59006 Lille, France. Electronic address:

Published: November 2017

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Article Abstract

Objective: The main goal of this study was to determine the in vitro susceptibility of strains collected from marketed probiotics to antibiotics used to treat community-acquired infections.

Methods: The minimum inhibitory concentrations (MICs) of 16 antibiotics were determined using a gradient strip (E test) or the agar dilution method for fidaxomicin.

Results: The probiotics demonstrated various antibiotic patterns. Bacterial probiotics are generally susceptible to most prescribed antibiotics orally administered, whereas yeast probiotics, such as Saccharomyces boulardii, are resistant.

Conclusion: Special attention must be paid to co-prescriptions of antibiotics and probiotics to ensure that the probiotic strain is not susceptible.

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http://dx.doi.org/10.1016/j.medmal.2017.07.001DOI Listing

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