AI Article Synopsis
- The study focuses on the role of chromosomal band 11q13 in oral cancer development, emphasizing the amplification of oncogenes and tumor-suppressor genes during the transformation of oral epithelial cells.
- It aims to review existing research on 11q13 amplification and introduce new concepts related to gene amplification relevant to oral squamous cell carcinoma (OSCC).
- The analysis includes key oncogenes and tumor-suppressor genes within the 11q13 region, their functions, and potential as therapeutic targets for oral cancer treatment.
Article Abstract
An important event in oral carcinogenesis is the amplification of chromosomal band 11q13, in which numerous oncogenes and some tumor-suppressor genes are localized and frequently co-amplified during the malignant transformation of oral epithelium. The objectives of this study were to review published data on the involvement of 11q13 amplification in oral cancer, to provide an update on novel concepts and terminology related to gene amplification, and to explore the composition of the 11q13 amplicon in OSCC, including its most relevant amplicon cores and potential drivers. We report on the critical oncogenes and tumor-suppressor genes in 11q13 that may play a major role in oral cancer, focusing on their functions, on the characteristics acquired by their amplification, and on their clinicopathological implications. Finally, we discuss the possible usefulness of the 11q13 region as a therapeutic target in oral cancer.
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| http://dx.doi.org/10.1016/j.oraloncology.2017.04.016 | DOI Listing |
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