To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834226 | PMC |
| http://dx.doi.org/10.1080/21541264.2017.1345354 | DOI Listing |
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