Probiotics are commonly prescribed as an adjuvant in the treatment of antibiotic-associated diarrhea caused by . We report the case of an immunocompromised 73-year-old patient on chemotherapy who developed var. fungemia in a central venous catheter during treatment of antibiotic-associated pseudomembranous colitis with the probiotic var. . Fungemia was resolved after interruption of probiotic administration without the need to replace the central venous line.
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http://dx.doi.org/10.1016/j.mmcr.2017.07.007 | DOI Listing |
Infect Dis Clin Microbiol
December 2024
Department of Medical Microbiology, Giresun University School of Medicine, Giresun, Türkiye.
Objective: is one of the leading causes of antibiotic-associated diarrhea. Recurrent infection (rCDI) is significant because of prolonged hospital stays, morbidity, and additional costs. Our study aimed to examine the characteristics of infections and investigate factors associated with recurrence.
View Article and Find Full Text PDFSci Rep
December 2024
Foodborne and Waterborne Diseases Research Center , Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clostridioides difficile is the leading cause of healthcare- and antibiotic-associated diarrhea. Surface layer protein A (SlpA), an essential component of the bacterium's outermost layer, contributes to colonization and inflammation. The peroxisome proliferator-activated receptor gamma (PPAR-γ) has been demonstrated to improve intestinal integrity and prevent inflammation in host cells.
View Article and Find Full Text PDFBackground: The most severe complications of antibiotic use are clostridial infection (CDI) and pseudomembranous colitis (PMC). There is a need for further study of these conditions and identification of their triggers.
Aim: To identify risk factors for severe forms of antibiotic-associated diarrhea caused by .
PLoS One
December 2024
The Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Background: Exposure of critically ill patients to antibiotics lead to intestinal dysbiosis, which often manifests as antibiotic-associated diarrhoea. Faecal microbiota transplantation restores gut microbiota and may lead to faster resolution of diarrhoea.
Methods: Into this prospective, multi-centre, randomized controlled trial we will enrol 36 critically ill patients with antibiotic-associated diarrhoea.
Anaerobe
December 2024
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
Clostridioides (Clostridium) difficile (C. difficile) infection (CDI), often severe when producing toxin A, toxin B, and CDT, can cause life-threatening fulminant infections, especially in vulnerable patients. This case report discusses a 39-year-old woman with no medical history who developed severe CDI after antibiotic treatment, leading to fatal hypovolemic shock.
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