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http://dx.doi.org/10.4097/kjae.2017.70.4.479DOI Listing

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Significant hypoglycemia secondary to icodextrin peritoneal dialysate in a diabetic patient.

Anesth Analg

June 2007

Department of Anesthesiology, Henry Ford Hospital, Detroit, Michigan 48202-9888, USA.

Icodextrin, a peritoneal dialysate commonly used in the renal failure patient with diabetes, may lead to an overestimation of blood glucose levels as determined by bedside glucometers. This spurious hyperglycemia can lead to significant morbidity if unrecognized. We describe a case of severe hypoglycemia caused by an unappreciated overestimation of blood glucose in a diabetic patient with concomitant chronic renal failure requiring peritoneal dialysis with icodextrin.

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Recently a number of glucose dehydrogenase-based point of care (POCT) systems for glucose monitoring were successfully introduced on the market. Icodextrin, a glucose polymer is widely used as an osmotic agent in continuous ambulatory peritoneal dialysis (CAPD). Its metabolites are substrates for glucose dehydrogenase, inducing an analytical error which is gaining importance in the determination of glucose in a hospital environment.

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