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SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer. | LitMetric

SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer.

Stem Cell Reports

Department of Biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China. Electronic address:

Published: August 2017

AI Article Synopsis

Article Abstract

It has been reported that functionally distinct cancer stem cells (CSCs) exist in human bladder cancer (BCa). Here, we found that Sox2, a transcription factor that is well characterized as a marker for stem cells, is upregulated in both mouse and human BCa. Sox2 expression is absent in normal urothelial cells, but it begins to be expressed in pre-neoplastic bladder tumors and continues to be expressed in invasive mouse BCa. Using s as a reporter of Sox2 transcriptional expression, we demonstrated that Sox2-expressing cells mark a subpopulation of tumor cells that fuel the growth of established BCa. SOX2-positive cells also expressed other previously reported BCa CSC markers, including Keratin14 (KRT14) and CD44v6. Ablation of Sox2-expressing cells within primary invasive BCa led to enhanced tumor regression, supporting the essential role of SOX2-positive cells in regulating BCa maintenance and progression. Our data show that Sox2 is a marker of bladder CSCs and indicate it as a potential clinical target for BCa therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550032PMC
http://dx.doi.org/10.1016/j.stemcr.2017.07.004DOI Listing

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