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BACKGROUND Massive chylous leakage represents a rare yet potentially life-threatening complication following neck dissection, and its occurrence is even less common in the context of endoscopic thyroid surgery. Chylous leakage poses significant clinical management challenges, encompassing prolonged hospitalization, nutritional deficiencies, electrolyte imbalances, and the potential for infection. It is imperative for surgeons to remain vigilant and proactive in recognizing and managing chylous leakage to mitigate its potential impact on patient outcomes.

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Background: Chylothorax is an accumulation of typically milky-appearing lymphatic fluid within the pleural cavity. High-output chylothorax may lead to a severe risk of death if not treated promptly. Several studies have reported the effectiveness of indocyanine green (ICG) for chylothorax following lung cancer surgery, esophagectomy, and congenital and recurrent idiopathic chylothorax.

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The activity of inhibitory interneurons has a profound role in shaping cortical plasticity. Somatostatin-expressing interneurons (SOM-INs) are involved in several aspects of experience-dependent cortical rewiring. We addressed the question of the barrel cortex SOM-IN engagement in plasticity formation induced by sensory deprivation in adult mice (2-3 months old).

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Novel therapeutic approaches in GEP-NETs based on genetic and epigenetic alterations.

Biochim Biophys Acta Rev Cancer

September 2022

Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medicine School, Alcalá University, Madrid, Spain. Electronic address:

Article Synopsis
  • Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) vary in prognosis based on factors like tumor location, grade, and stage, with surgery as the only cure for localized cases and systemic therapy for advanced ones.
  • * In the past, treatment options were mostly limited to ineffective chemotherapy, but newer drugs such as somatostatin analogues and targeted therapies have improved the therapeutic approach.
  • * Recent advancements in genomic sequencing have opened up new insights into the genetic basis of GEP-NETs, paving the way for personalized treatment strategies and better understanding of treatment resistance.
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