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The first international mini-symposium on methionine restriction and lifespan.
Front Genet
May 2014
Orentreich Foundation for the Advancement of Science, Cold Spring NY, USA.
It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et al., 1993).
View Article and Find Full Text PDFMethionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.
Metabolism
November 2013
Orentreich Foundation for the Advancement of Science, Inc., 855 Route 301, Cold Spring-on-Hudson, NY 10516, USA. Electronic address:
Objective: This study investigated the effects of dietary methionine restriction (MR) on the progression of established hepatic steatosis in the leptin-deficient ob/ob mouse.
Material/methods: Ten-week-old ob/ob mice were fed diets containing 0.86% (control-fed; CF) or 0.
Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density.
PLoS One
June 2013
Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America.
Dietary methionine restriction (MR) extends lifespan, an effect associated with reduction of body weight gain, and improvement of insulin sensitivity in mice and rats as a result of metabolic adaptations in liver, adipose tissue and skeletal muscle. To test whether MR confers resistance to adiposity and insulin resistance, C57BL/6J mice were fed a high fat diet (HFD) containing either 0.86% methionine (control fed; CF) or 0.
View Article and Find Full Text PDFEffect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance.
Metabolism
April 2013
Department of Pharmacology, University of Oxford, UK.
Objectives: Methionine-restricted (MR) rats, which are lean and insulin sensitive, have low serum total cysteine (tCys) and taurine and decreased hepatic expression and activity indices of stearoyl-coenzyme A desaturase-1 (SCD1). These effects are partly or completely reversed by cysteine supplementation. We investigated whether reversal of MR phenotypes can be achieved by other sulfur compounds, namely taurine or N-acetylcysteine (NAC).
View Article and Find Full Text PDFGenomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle.
J Nutrigenet Nutrigenomics
May 2013
Orentreich Foundation for the Advancement of Science, Inc, Cold Spring-on-Hudson, NY, USA.
Background/aims: Methionine restriction (MR) is a dietary intervention that increases lifespan, reduces adiposity and improves insulin sensitivity. These effects are reversed by supplementation of the MR diet with cysteine (MRC). Genomic and metabolomic studies were conducted to identify potential mechanisms by which MR induces favorable metabolic effects, and that are reversed by cysteine supplementation.
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