The rational use of medicines (URM) is considered one of the key elements recommended by the World Health Organization (WHO) for pharmaceutical policies. The excessive increase in the use of medicines in many countries has been identified as a major barrier to the achievement of URM and is part of a phenomenon called the 'pharmaceuticalization' of the society. This paper aims to present innitiatives to rationalize the use of methylphenidate and its limits in Brazil, considering the concept of pharmaceuticalization of the society. It is an exploratory study, based on a narrative review of the scientific literature. Controversies about the uses of methylphenidate make it a good example of this phenomenon and may help in the reflection and construction of new paths to the limits found by the concept of rational use of medicines.
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http://dx.doi.org/10.1590/1413-81232017228.08622017 | DOI Listing |
J Med Chem
January 2025
Department of Chemical and Systems Biology, Stanford Cancer Institute, School of Medicine Stanford University, Stanford, California 94305-6104, United States.
Molecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase, thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind cereblon (CRBN) and recruit neosubstrates. Through explorative synthesis of a glutarimide-based library, we discovered a series of molecules that induce casein kinase 1 alpha (CK1α) degradation.
View Article and Find Full Text PDFAddiction
January 2025
Harvard Medical School and Center for Addiction Medicine, Recovery Research Institute, at Massachusetts General Hospital, Boston, MA, USA.
Background: The definition of 'recovery' has evolved beyond merely control of problem substance use to include other aspects of health and wellbeing (known as 'recovery capital') which are important to prevent relapse to problematic alcohol or other drug (AOD) use. Developing a Recovery Oriented System of Care (ROSC) requires consideration of interventions or services (Recovery Support Services, RSS) designed to build recovery capital which are often delivered alongside established treatment structures. Lived experience and its application to the process of engaging people, changing behaviour and relapse prevention is an essential part of these services.
View Article and Find Full Text PDFExpert Rev Vaccines
January 2025
Hospital Universitario La Paz-IdiPAZ, Madrid, Spain.
Introduction: Vaccines to prevent important infections involving, e.g. influenza viruses, severe acute respiratory syndrome-causing coronaviruses (e.
View Article and Find Full Text PDFFront Aging Neurosci
January 2025
Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macao SAR, China.
Objectives: This study aimed to explore the rationality of the social networks-depression-cognitive impairment pathway and to provide recommendations for the development of mild cognitive impairment intervention strategies.
Methods: A cross-sectional survey was conducted in 2021. Sixteen urban communities in Xi 'an, Shaanxi China were selected as sample sites.
Front Pediatr
January 2025
Department of Cell Immunotherapy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Corticosteroids are used for toxicity management, raising concerns about whether they may affect the anti-leukemic effects of chimeric antigen receptor (CAR)-T cells.
Methods And Results: In this study, we retrospectively analyzed patients (fined two subgroups based on disease burden. Of the 75 cases in the low disease burden (LDB) group (MRD < 5%, no extramedullary disease), there was no significant difference between the use of steroids and event-free survival (EFS) ( = 0.
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