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Recombinant Live-Attenuated Vaccine for Veterinary Use.
Vaccines (Basel)
November 2024
Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, Brazil.
Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens.
View Article and Find Full Text PDFInter-island variability in trace elements and trophic ecology of Brown Booby (Sula leucogaster) in the South Atlantic.
Environ Pollut
January 2025
Olaf Malm Laboratory of Environmental Studies (LEA-OM), Carlos Chagas Filho Biophysics Institute (IBCCF), Federal University of Rio de Janeiro (UFRJ), 21941-902, Rio de Janeiro, Brazil; Laboratory of Oceanology, Freshwater and Oceanic Sciences Unit of Research (FOCUS), University of Liege, Belgium.
This study investigates essential (Mg, Ca, Fe, Mn, Cu, Zn, Se, Ni) and non-essential (Li, Be, Cr, Rb, Sr, Cs, Cd, Sn, Ba, and Pb) element concentrations and stable isotope (δC, δN, δS) compositions in feathers of Brown Boobies (Sula leucogaster) from three distinct Atlantic islands: the Archipelagos of Saint Peter and Saint Paul (SPSP), Abrolhos, and Cagarras. We aimed to investigate the ecological and environmental factors influencing these seabird populations and assess potential variations in contaminant exposure and dietary habits based on location, sex, and maturity stages. Our finding revealed significant geographical differences in trace element concentrations.
View Article and Find Full Text PDFCharacterization of a novel acidic phospholipase A isolated from the venom of Bothrops mattogrossensis: From purification to structural modeling.
Int J Biol Macromol
December 2024
Laboratory of Cellular Immunology Applied to Health, Oswaldo Cruz Foundation, FIOCRUZ Rondônia, Porto Velho, RO, Brazil; Department of Medicine, Federal University of Rondonia (UNIR), Porto Velho, RO, Brazil. Electronic address:
Phospholipases A (PLAs) are highly prevalent in Bothrops snake venom and play a crucial role in inflammatory responses and immune cell activation during envenomation. Despite their significance, the specific role of PLAs from Bothrops mattogrossensis venom (BmV) in inflammation is not fully understood. This study sought to isolate and characterize a novel acidic PLA from BmV, designated BmPLA-A, and to evaluate its effects on human umbilical vein endothelial cells (HUVECs), with a specific focus on cytotoxicity, adhesion, and detachment.
View Article and Find Full Text PDFAbiotic Factors Modulating Metabolite Composition in Brown Algae (Phaeophyceae): Ecological Impacts and Opportunities for Bioprospecting of Bioactive Compounds.
Mar Drugs
December 2024
Laboratory of Natural Products from Seaweeds (ALGAMAR), Department of Marine Biology, Institute of Biology, Federal Fluminense University, Niterói 24210-201, RJ, Brazil.
Brown algae are vital structural elements and contributors to biodiversity in marine ecosystems. These organisms adapt to various environmental challenges by producing primary and secondary metabolites crucial for their survival, defense, and resilience. Besides their ecological role, these diverse metabolites have potential for biotechnological applications in industries including pharmaceuticals, cosmetics, and food.
View Article and Find Full Text PDFStructural heart disease in the tropics: A comprehensive review.
Curr Probl Cardiol
December 2024
Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia; Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia.
Structural heart disease (SHD) remains a significant global health challenge, disproportionately impacting populations in tropical regions where the burden of infectious diseases, limited healthcare infrastructure, and socio-economic disparities exacerbate the issue. The tropics are uniquely affected by conditions such as rheumatic heart disease (RHD), endomyocardial fibrosis, tropical cardiomyopathies, and pericardial diseases, often resulting from or complicated by endemic infections like malaria, dengue, tuberculosis, and parasitic diseases. Moreover, Human Immunodeficiency Virus-Associated Cardiac Disease (HIVAC) represents an emerging concern in regions with high HIV prevalence, adding complexity to the interplay between infectious and structural cardiac conditions.
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