Insights into sensorimotor control of balance were examined by the assessment of perturbed and unperturbed balance in standing and handstand postures. During perturbed and unperturbed balance in standing, the most prevalent control strategy was an ankle strategy, which was employed for more than 90% of the time in balance. During perturbed and unperturbed balance in handstand, the most prevalent control strategy was a wrist strategy, which was employed for more than 75% of the time in balance. In both postures, these strategies may be described as a single segment inverted pendulum control strategy, where the multi-segment system is controlled by torque about the most inferior joint with compensatory torques about all superior joints acting in the same direction to maintain a fixed orientation between superior segments. In contrast to previous literature, surprisingly little time was spent in a mixed strategy, representing less than 1% of time in standing balance and approximately 2% of time in handstand balance. Findings indicate that although the central nervous system may employ a number of control strategies during a trial, these strategies are employed individually rather than simultaneously.
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http://dx.doi.org/10.1098/rsos.161018 | DOI Listing |
J Inorg Biochem
December 2024
Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina; Instituto de Química Física de Los Materiales, Medio Ambiente y Energía (INQUIMAE), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina. Electronic address:
Here, we show that the replacement of the distal residues Asp and/or Arg of the DyP peroxidases from Bacillus subtilis and Pseudomonas putida results in functional enzymes, albeit with spectroscopically perturbed active sites. All the enzymes can be activated either by the addition of exogenous HO or by in situ electrochemical generation of the reactive oxygen species (ROS) OH, O and HO. The latter method leads to broader and upshifted pH-activity profiles.
View Article and Find Full Text PDFPLoS One
December 2024
Joint Department of Biomedical Engineering, University of North Carlina at Chapel Hill & North Carolina State University, Chapel Hill, NC, United States of America.
Rehabilitation to prevent falls should not only directly address intrinsic and extrinsic factors, but also the neuropsychology of falls to promote safe and independent mobility in our aging population. The purpose of this study was to determine the relation between falls self-efficacy and objective responses to a series of walking balance perturbations. 29 healthy younger adults and 28 older adults completed four experimental trials, including unperturbed walking and walking while responding to three perturbations: mediolateral optical flow, treadmill-induced slips, and lateral waist-pulls; and three self-reported questionnaires: Activity-specific Balance Confidence, Falls Efficacy Scale, and the Fear of Falling Questionnaire-Revised.
View Article and Find Full Text PDFBrain Sci
November 2024
College of Computer Science and Software Engineering, Hohai University, Nanjing 211100, China.
To investigate the behavior of spiking neural networks (SNNs), the sensitivity of input perturbation serves as an effective metric for assessing the influence on the network output. However, existing methods fall short in evaluating the sensitivity of SNNs featuring biologically plausible leaky integrate-and-fire (LIF) neurons due to the intricate neuronal dynamics during the feedforward process. This paper first defines the sensitivity of a temporal-coded spiking neuron (SN) as the deviation between the perturbed and unperturbed output under a given input perturbation with respect to overall inputs.
View Article and Find Full Text PDFSci Total Environ
December 2024
BRGM, 3 av. C. Guillemin, 45060 Cedex 02 Orleans, France.
Groundwater level (GWL) can vary over a wide range of timescales. Previous studies highlighted that low-frequency variability (interannual (2-8 years) to decadal (>10 years)) originating from large-scale climate variability, represents a significant part of GWL variance. It remains an open question, however, how GWL, including extremes, may respond to changes in large-scale climate forcing, affecting precipitation variability.
View Article and Find Full Text PDFPersistent viral infections are associated with long-term health issues and prolonged transmission. How external perturbations after initial exposure affect the duration of infection is unclear. We discovered that murine astrovirus, an enteric RNA virus, persists indefinitely when mice remain unperturbed but is cleared rapidly after cage change.
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