AI Article Synopsis
- Long-term potentiation (LTP) and memory formation rely on the activation of cyclic nucleotides, specifically cGMP and cAMP.
- Recent findings show that both cGMP and cAMP increase the production of amyloid-beta (Aβ) peptides, with cAMP promoting hippocampal LTP by enhancing amyloid precursor protein (APP) synthesis.
- The study highlights cGMP's role in the trafficking of APP within cells, suggesting it aids in Aβ production by facilitating APP movement to the endolysosomal compartment without altering APP expression.
Article Abstract
Long-term potentiation (LTP) and the process of memory formation require activation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Notably, recent evidence indicated that both cyclic nucleotides boost the production of amyloid-beta (Aβ) peptides. In particular, cAMP was shown to favor hippocampal LTP by stimulating the synthesis of the amyloid precursor protein APP, whereas cGMP was found to enhance LTP and to improve memory by increasing Aβ levels without affecting the expression of APP. The results of the present study substantiate that cGMP has a role in the endocytic pathway of APP and suggest a scenario where the cyclic nucleotide enhances the production of Aβ by favoring the trafficking of APP from the cell cortex to the endolysosomal compartment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mad.2017.08.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!