AI Article Synopsis

  • The demand for bone graft materials is rising, with natural coral converted into hydroxyapatite (HA) and silicon-substituted for enhanced properties.
  • Different ratios of silicon-substituted HA mixed with β-tricalcium phosphate (TCP) were tested in rats for bone regeneration.
  • The mixture with a 60:40 ratio (S60T40) demonstrated the fastest bone growth in four weeks, indicating Si-HA/TCP's potential as an effective bone graft material.

Article Abstract

The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456508PMC
http://dx.doi.org/10.3390/ma9020097DOI Listing

Publication Analysis

Top Keywords

bone graft
12
bone
9
bone regeneration
8
rat calvarial
8
calvarial bone
8
bone defect
8
defect model
8
graft materials
8
weeks 005
8
regeneration mixture
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!