AI Article Synopsis
- The study evaluated gamma irradiation and electron beams for sterilizing biodegradable scaffolds made from specific terpolymers.
- Gamma irradiation at 15 kGy significantly reduced the glass transition temperature and molecular weight of the scaffolds, while electron beam irradiation showed no major structural changes at the same dose.
- Overall, electron beam sterilization is considered superior because it preserves the scaffolds' physicochemical properties better than gamma irradiation, with no impact on their shape memory behavior.
Article Abstract
The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide--glycolide--trimethylene carbonate) and poly(l-lactide--glycolide--ɛ-caprolactone). The impact of mentioned sterilization techniques on the structure of the scaffolds before and after the sterilization process using irradiation doses ranged from 10 to 25 kGy has been investigated. Treatment of the samples with gamma irradiation at 15 kGy dose resulted in considerable drop in glass transition temperature (T) and number average molecular weight (M). For comparison, after irradiation of the samples using an electron beam with the same dose, no significant changes in structure or properties of examined scaffolds have been noticed. Higher doses of irradiation via electron beam caused essential changes of the scaffolds' pores resulting in partial melting of their surface. Nevertheless, obtained results have revealed that sterilization with electron beam, when compared to gamma irradiation, is a better method because it does not affect significantly the physicochemical properties of the scaffolds. Both used methods of sterilization did not influence the shape memory behavior of the examined materials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456516 | PMC |
| http://dx.doi.org/10.3390/ma9010064 | DOI Listing |
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