AI Article Synopsis
- The study investigated the relationship between antipsychotic medications and changes in heart rhythm (QT/QTc duration) in male patients with psychotic disorders.
- A review of 184 patient charts revealed that the majority had normal QTc values, with only a small percentage showing slight increases, particularly associated with specific medications.
- The findings indicated that aripiprazole had the least impact on QT/QTc prolongation, while paliperidone showed a more significant effect, particularly on QT duration.
Article Abstract
Objective: We explored the potential association between antipsychotics and QT/QTc duration changes in hospitalized male patients with psychotic disorders.
Methods: The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patients who were treated with one atypical antipsychotic at the time of the ECG recording were 109/184 (59.2%). QT/QTc were compared considering the atypical antipsychotic received.
Results: 96.3% ( = 105/109) of the sample showed QTc values ≤ 430 ms; 4 patients (3.7%) had QTc values between 430 and 450 msec (2 with paliperidone, 1 with risperidone, and 1 with olanzapine). The mean QT duration of the overall sample was 368.0 ± 28.0 and the mean QTc 400.1 ± 17.8. QTc values did not reveal statistically significant differences. QT values were significantly different (chi-square = 17.3; df = 5; = .004). Statistically significant differences between aripiprazole and paliperidone (349.0 ± 28.3 versus 390.5 ± 29.8; = .002) and between clozapine and paliperidone (361.1 ± 22.43 versus 390.5 ± 29.8; = .033) were found.
Conclusions: Aripiprazole was the least interfering neuroleptic with QT/QTc. Paliperidone was the atypical neuroleptic with the most relevant difference with aripiprazole, but only on QT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529641 | PMC |
| http://dx.doi.org/10.1155/2017/1951628 | DOI Listing |
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