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| http://dx.doi.org/10.1016/j.ijcha.2015.06.002 | DOI Listing |
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Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo.
Biomed Pharmacother
June 2024
Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., Krakow 31-121, Poland. Electronic address:
Nowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role.
View Article and Find Full Text PDFSacubitril/valsartan reversal of left ventricular remodeling is associated with improved hemodynamics in resistant hypertension.
Hellenic J Cardiol
April 2024
Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong, China. Electronic address:
Background: Sacubitril/valsartan (S/V) has been shown to be an effective antihypertensive drug combination. However, its therapeutic effects on blood pressure (BP), hemodynamics, and left ventricular (LV) remodeling in resistant hypertension (RHTN) remain unclear.
Methods: Eighty-six patients completed this self-control study, during which olmesartan was administered within the first 8 weeks (phase 1), followed by S/V within the second 8 weeks (phase 2), with nifedipine and hydrochlorothiazide taken as background medications.
AT1R blocker prevents mental stress induced retrograde blood flow in overweight/obese men.
Physiol Rep
January 2023
Department of Physiology and Pharmacology, Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Brazil.
The main goal was to determine the impact of mental stress (MS) on blood flow regulation in overweight/obese men. Fourteen overweight/obese men (27 ± 7 years; 29.8 ± 2.
View Article and Find Full Text PDFTranscutaneous Vagus Nerve Stimulation Ameliorates the Phenotype of Heart Failure With Preserved Ejection Fraction Through Its Anti-Inflammatory Effects.
Circ Heart Fail
August 2022
Cardiovascular Section, Department of Medicine (K.E., M.N., L.M., S.W., S.S.), University of Oklahoma Health Science Center, Oklahoma City.
Background: A systemic proinflammatory state plays a central role in the development of heart failure with preserved ejection fraction (HFpEF). Low-level transcutaneous vagus nerve stimulation (LLTS) suppresses inflammation in animals and humans, mediated by an α7nAchR (alpha7 nicotinic acetylcholine receptor)-dependent pathway. We examined the effects of LLTS on cardiac function, inflammation, and fibrosis in the presence of α7nAchR pharmacological blockade in a rat model of HFpEF.
View Article and Find Full Text PDFOlmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats.
Drug Deliv
December 2022
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Olmesartan medoxomil (OM) is an angiotensin receptor blocker. This study aimed to investigate the effects of OM self-microemulsifying drug delivery system (OMS) in trinitrobenzene sulfonic acid (TNBS)-induced acute colitis in rats. Besides two control groups, five TNBS-colitic-treated groups ( = 8) were given orally sulfasalazine (100 mg/kg/day), low and high doses of OM (3.
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