AI Article Synopsis
- - A rare case of acute liver injury was reported in a 41-year-old man following treatment for internal hemorrhoids using a submucosal injection of aluminum potassium sulfate and tannic acid (ALTA) combined with lidocaine.
- - The liver injury was identified as hepatocellular and cholestatic, but the exact mechanism behind the injury couldn't be determined; high levels of eosinophils and immunoglobulin E were noted, while a lymphocyte stimulation test returned negative results after 25 days.
- - The patient's liver condition improved significantly after two weeks of fluid replacement therapy, highlighting the need for further analysis of similar cases in the future as this is the first reported severe liver disorder linked to ALTA treatment.
Article Abstract
We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury, and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa, from the rectum to the anus, and this is the first description of a case that developed a severe liver disorder after this treatment; hence, an analysis of future cases as they accumulate is desirable.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526772 | PMC |
| http://dx.doi.org/10.3748/wjg.v23.i27.5034 | DOI Listing |
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