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TBC1D20 coordinates vesicle transport and actin remodeling to regulate ciliogenesis.
J Cell Biol
April 2025
Department of Genetics and Cell Biology, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
TBC1D20 deficiency causes Warburg Micro Syndrome in humans, characterized by multiple eye abnormalities, severe intellectual disability, and abnormal sexual development, but the molecular mechanisms remain unknown. Here, we identify TBC1D20 as a novel Rab11 GTPase-activating protein that coordinates vesicle transport and actin remodeling to regulate ciliogenesis. Depletion of TBC1D20 promotes Rab11 vesicle accumulation and actin deconstruction around the centrosome, facilitating the initiation of ciliogenesis even in cycling cells.
View Article and Find Full Text PDFPsychometric Validation of the Dating Violence Questionnaire (DVQ-R) in Ecuadorians.
Behav Sci (Basel)
January 2025
Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain.
Gender-based violence among young people is a pressing global problem, causing injury and disability to women and posing physical, mental, sexual, and reproductive health risks. This study aimed to psychometrically validate the Dating Violence Questionnaire-Revised (DVQ-R) in a sample of 340 Ecuadorian university students. The study included 340 male and female students from two universities in Ecuador.
View Article and Find Full Text PDFCluster of symptoms in kidney failure: A systematic review.
Heliyon
January 2025
Institute of Biomedicine of Málaga (IBIMA), 29010, Málaga, Spain.
Background: Chronic kidney disease is a global problem characterized by a progressive decrease in kidney function with associated symptoms. A better understanding of these symptoms could lead to the development of personalized strategies.
Objective: This systematic review aims to describe the clusters of symptoms in kidney failure and categorize them according to their time of onset and how disabling they are for patients.
Medical School Curriculum Evaluation to Improve Health Equity Education.
J Gen Intern Med
January 2025
Yale School of Medicine, New Haven, CT, USA.
Following the birth of Black Lives Matter, USA medical students advocated for greater commitment to health equity from their schools. In response to such concerns, in 2015, the Yale School of Medicine formed a committee for diversity, inclusion, and social justice and a committee on lesbian, gay, bisexual, transgender, queer, questioning, and intersex affairs. Based on their efforts, our Educational Policy and Curriculum Committee commissioned a student-faculty-led task force to survey the curriculum and make recommendations toward the creation of a health equity curriculum.
View Article and Find Full Text PDFForms and correlates of child maltreatment among autistic children involved in child protection services.
Front Child Adolesc Psychiatry
August 2024
Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
Background: Child maltreatment is a significant social problem impacting both health and society, with severe and enduring consequences. Certain children, such as those with neurodevelopmental conditions like autism, may be more at risk of experiencing maltreatment. However, little research has examined the characteristics of these children.
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