Cotyledonoid dissecting leiomyoma is a leiomyoma variant exhibiting unusual growth patterns. We aimed to demonstrate this, as well as to point out another feature that has not been previously reported. A congested, multinodular myomectomy specimen was resected. Histologically, smooth muscle fascicles with marked vascularity and extensive hydropic degeneration were detected. A total of 2 mitoses per 10 high power fields were counted, and the K-67 index was of 2-3%. We encountered atypical bizarre cells that have not been previously reported. Coagulative necrosis was not present. The patient was alive and well 36 months after surgery, with no evidence of recurrence. Albeit the gross aggressive appearance, cotyledonoid dissecting leiomyomas are benign in nature. To this day, atypical cells have not been reported in this type of tumor. Despite the presence of symplastic features, cotyledonoid dissecting leiomyomas are clinically benign entities. Surgeons and pathologists should be acquainted with this variant.
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http://dx.doi.org/10.1055/s-0037-1604057 | DOI Listing |
Int J Surg Pathol
January 2025
Department of Pathology, Université de Montréal, Montreal, Quebec, Canada.
J Midlife Health
October 2024
Department of Pathology, Esic Medical College and Hospital, Faridabad, Haryana, India.
BMJ Case Rep
September 2024
Department of Obstetrics and Gynecology, Toho University Medical Center Sakura, Chiba, Japan.
Cotyledonoid dissecting leiomyoma (CDL) is a rare benign uterine leiomyoma that macroscopically shows multinodular placenta-like growth. Its border with the myometrial layer is unclear, making it clinically difficult to differentiate from uterine sarcoma. CDL is often misdiagnosed.
View Article and Find Full Text PDFClin Pathol
September 2024
Department of Obstetrics and Gynecology, Sasebo City General Hospital, Sasebo, Japan.
J Minim Invasive Gynecol
January 2025
Department of Obstetrics and Gynecology (Drs. Kinoshita, Fukuda, and Osuga), The University of Tokyo, Tokyo, Japan.
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