AI Article Synopsis
- Topical permethrin is the most effective treatment for classic scabies, with strong evidence supporting its use (SOR: A).
- Topical treatments like lindane, crotamiton, and others are less effective than permethrin but show similar effectiveness among themselves (SOR: B).
- Oral ivermectin is an alternative treatment that can be effective, especially in endemic areas, but is not as reliable as topical permethrin (SOR: B).
Article Abstract
Topical permethrin is the most effective treatment for classic scabies (strength of recommendation [SOR]: A, meta-analyses with consistent results). Topical lindane and crotamiton are inferior to permethrin but appear equivalent to each other and benzyl benzoate, sulfur, and natural synergized pyrethrins (SOR: B, limited randomized trials). Although not as effective as topical permethrin, oral ivermectin is an effective treatment compared with placebo (SOR: B, a single small randomized trial). Oral ivermectin may reduce the prevalence of scabies at one year in populations with endemic disease more than topical permethrin (SOR: B, a single randomized trial).
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