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Natural Products in Precision Cryptococcal Meningitis: Phytochemical Screening of Glycyrrhiza glabra Plant against Cryptococcus neoformans Farnesyltransferase (FTase).
Chem Biodivers
December 2024
Noakhali Science and Technology University, Microbiology, Sonapur, Noakhali, BANGLADESH.
Cryptococcus neoformans, the most opportunistic fungal pathogen, causes cryptococcal meningitis. Based on molecular docking and ADME/toxicity analysis, the top two lead compounds selected from a screening of 5,807 phytochemical compounds from 29 medicinal plants were CID_8299 and CID_71346280, with docking scores of -5.786 and -6.
View Article and Find Full Text PDFComparison of positive BioFire FilmArray meningitis/encephalitis (ME) panels, CSF cultures, CSF parameters, clinical presentation and in-patient mortality among patients with bacterial and fungal meningitis.
Microbiol Spectr
December 2024
Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.
Unlabelled: The BioFire FilmArray meningitis/encephalitis panel (MEP) was brought to the University of Kentucky in 2016 to aid in the identification of community-acquired meningitis and encephalitis (ME). This panel has shown variable performance with some institutions showing high sensitivity and specificity for many pathogens but others seeing false positives during clinical use. We evaluated the panel's performance using retrospective chart review of patients at the University of Kentucky from October 2016 to September 2022, including 7,551 MEP results.
View Article and Find Full Text PDFComparing the Performance of Two Cryptococcal Antigen Detection Tests: Chemiluminescence vs Colloidal Gold Methods.
Infect Drug Resist
December 2024
Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Objective: To compare the performance of a new chemiluminescence method with that of the traditional colloidal gold method for cryptococcal antigen (CrAg) detection.
Methods: Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. Cryptococcal antigen (CrAg) testing from serum and cerebrospinal fluid (CSF) has been regarded as the gold standard for early diagnosis.
Idiopathic eosinophilia complicated with cryptococcal meningitis: a case report.
J Int Med Res
December 2024
Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Idiopathic eosinophilia, characterized by unexplained peripheral blood eosinophilia after ruling out secondary causes, is an extremely rare condition. Cryptococcal meningitis is a life-threatening opportunistic infection that primarily affects immunocompromised individuals, such as those with advanced AIDS or leukemia. In this report, we present a unique case of idiopathic eosinophilia concurrent with cryptococcal meningitis, which, to the best of our knowledge, is the first such case described globally.
View Article and Find Full Text PDFThe molecular mechanisms by which the NLRP3 inflammasome regulates blood-brain barrier permeability following cryptococcal meningitis.
Heliyon
December 2024
Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Objective: To investigate the mechanism underlying the regulation of blood-brain barrier permeability changes during cryptococcal meningitis by NLRP3 and Vimentin.
Methods: Sprague-Dawley rats were treated with WT Cryptococcus neoformans (Cn) or CPS1-/- Cn. Neuronal apoptosis was assessed using TUNEL staining, and pathological changes were observed using electron microscopy and HE staining.
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